Sublingual, as opposed to oral, administration of Nifedipine (Adalat) has gained wide popularity as the method of choice when the most rapid onset of anti-hypertensive action is required
Nifedipine is 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4- (2-nitrophenyl)-, dimethyl ester, C 17 H 18 N 2 O 6, and has the structural formula: Nifedipine is a yellow crystalline Sublingual nitroglycerin may be taken for acute manifestations of angina, particularly during nifedipine titration
Dosis dapat ditingkatkan tiap 7–14 hari jika perlu
Nifedipine dapat diberikan dengan dosis awal 20 mg, dan diulang setiap 30 menit jika kontraksi masih terjadi
It is used to treat high blood pressure (hypertension) and chest pain (angina)
Not FDA approved for children
Peritoneal dialysis (PD) or hemodialysis (HD): You may report side effects to FDA at 1-800-FDA-1088
Pemberian nifedipin secara sublingual meningkatkan efek hipotensi melalui vasodilatasi perifer
BELBUCA, BUAVAIL, BUTRANS, SUBOXONE, SUBUTEX, ZUBSOLV
If you want to discuss an alternative approach, contact the Office of Generic Drugs
Nifedipine extended release tablets are formulated as Nifedipine GITS (Gastrointestinal Therapeutic System)
For extended release tablets, the usual dose is 30 or 60 mg once daily
Overdose
Br J Obstet Gynaecol
The extended-release tablet uses two release-rate controlling mechanisms: a primary polymer matrix core composed of drug with excipients and a secondary enteric coating surrounding the core
1996; 276:1328–1331