A 5-year-old child is reported who, after an acute ingestion of chlorpromazine, developed an absolute neutropenia
See more DEFINITIONS Neutropenia is defined as an absolute neutrophil count (ANC) <1500/microL
Neutrophils are destined to undergo apoptosis, with a life span in the circulation of 8 to 20 hr
Carefully monitor patients with clinically significant neutropenia for fever or other signs and symptoms of infection and treat promptly if they occur
Chlorpromazine (klor proe' ma zeen) is a tricyclic aliphatic phenothiazine which acts by postsynaptic inhibition of dopamine receptors
What is chlorpromazine? Chlorpromazine is a phenothiazine (FEEN-oh-THYE-a-zeen) that is used to treat psychotic disorders such as schizophrenia or manic
WARNINGS)
Chlorpromazine is a phenothiazine that was once the most commonly prescribed antipsychotic agent, but that is now rarely used
Chlorpromazine should generally not be used in children <6 months of age unless the condition to be treated is potentially life-threatening; Leukopenia and neutropenia temporally related to antipsychotic agents, including chlorpromazine, reported during clinical trial and/or postmarketing experience
It is available in tablets for oral administration
In 1979, a 10-yr nation-wide study in Sweden indicated that the incidence of drug-induced neutropenia was 1 case/million
Chlorpromazine suntik
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Dizziness, sleepiness, and feeling less stable may happen with Thorazine (chlorpromazine injection)
Leukopenia, Neutropenia and Agranulocytosis
Less Common Side Effects
Background: The historical process of discovery and clinical introduction of chlorpromazine, one of the greatest advances of 20th century medicine and history of psychiatry, is analyzed
Leukopenia, Neutropenia and Agranulocytosis
"take the hydrochlorothiazide in the morning
Affected patients typically experience severe neutropenia within several weeks to several months after first Severe neutropenia can lead to serious infection and death
Agranulocytosis, leukopenia, and neutropenia reported with antipsychotic use; periodic blood count assessment recommended in patients with history of risk factors, including history of drug-induced leuko/neutropenia or preexisting low WBC; Methods
Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions